STRING Database MCP MCP server

The STRING MCP server connects AI agents to the STRING protein-protein interaction database, allowing for queries on interactions, enrichment, annotations, homology, and PPI networks. It provides structured responses with metadata hints to help models interpret results and choose follow-up queries, supporting tools for resolving proteins, finding partners, generating network images, and running functional enrichment analyses.

Endpoint and access

No sign-in: your client connects and lists tools immediately, with no account or key.

No sign-inEndpoint checked 2026-10-05Operated by STRING

MCP endpoint (Streamable HTTP)

https://mcp.string-db.org/

Vendor documentation

What you can do with it

Find interaction partners of TP53 in human
Run functional enrichment for protein sets
Find homologs of human EGFR in mouse
Generate STRING network image URLs

Tools advertised by the last live check:

string_resolve_proteins
string_interactions_query_set
string_all_interaction_partners
string_visual_network
string_network_clustering
string_network_link
string_homology
string_interaction_evidence
string_enrichment
string_functional_annotation
string_enrichment_image_url
string_ppi_enrichment
string_proteins_for_term
string_sequence_search
string_query_species
string_create_file
string_help

Connect from your client

Each snippet registers the same endpoint; pick the client you use.

This server is operated by the named third party. Listing and endpoint checks are not an endorsement or a security audit. Review the operator's permissions, terms, and data handling before connecting. How listings are checked and corrected.

Claude Code

Run this once in a terminal. It registers a Streamable HTTP server. Use --scope project to write .mcp.json for the repo.

Claude Code configuration

claude mcp add --transport http string-database-mcp https://mcp.string-db.org/

Codex

Run this once. Codex stores MCP servers in ~/.codex/config.toml (or .codex/config.toml in a trusted project).

Codex configuration

codex mcp add string-database-mcp --url https://mcp.string-db.org/

Cursor

Merge this server into .cursor/mcp.json in your project, then enable string-database-mcp in your MCP settings.

Cursor configuration

{
  "mcpServers": {
    "string-database-mcp": {
      "url": "https://mcp.string-db.org/"
    }
  }
}

Cline

Merge this into cline_mcp_settings.json (Cline → MCP Servers → Configure). The type must be streamableHttp for a remote HTTP server.

Cline configuration

{
  "mcpServers": {
    "string-database-mcp": {
      "type": "streamableHttp",
      "url": "https://mcp.string-db.org/",
      "disabled": false
    }
  }
}

VS Code

Merge this server into .vscode/mcp.json. Use MCP: List Servers to start string-database-mcp and inspect its tools.

VS Code configuration

{
  "servers": {
    "string-database-mcp": {
      "type": "http",
      "url": "https://mcp.string-db.org/"
    }
  }
}

Gemini CLI

Run this once. It writes .gemini/settings.json in the current project; pass --scope user for ~/.gemini/settings.json.

Gemini CLI configuration

gemini mcp add --transport http string-database-mcp https://mcp.string-db.org/

Claude Desktop

Merge this into claude_desktop_config.json (macOS: ~/Library/Application Support/Claude/, Windows: %APPDATA%\Claude\), then restart Claude Desktop.

Claude Desktop configuration

{
  "mcpServers": {
    "string-database-mcp": {
      "url": "https://mcp.string-db.org/"
    }
  }
}

Windsurf

Merge this into ~/.codeium/windsurf/mcp_config.json, then refresh MCP in Cascade. Windsurf remote servers use serverUrl, not url.

Windsurf configuration

{
  "mcpServers": {
    "string-database-mcp": {
      "serverUrl": "https://mcp.string-db.org/"
    }
  }
}

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