Rosetta MCP Server

An MCP server enabling AI coding agents to interact with Rosetta, PyRosetta, and Biotite for protein modeling and design. It supports running RosettaScripts, validating XML protocols, translating code between frameworks, scoring structures, and querying documentation directly from the assistant.

Package and access

Local package with source-attributed installation metadata. Koskamo does not execute packages during review.

Community listingLocal stdioSource reviewed; not executedPublished by Ariel J. Ben-Sasson

Vendor documentation

What you can do with it

Run RosettaScripts for protein design
Translate between Rosetta and Biotite code
Validate XML protocols against schema
Score protein structures and query docs

Source and maintenance

Community listingRegistry 1.3.1

mcp-registry: io.github.Arielbs/rosetta-mcp-server@1.3.1 Source repository

Maintenance checked: Oct 31, 2026, 10:59 PM UTC

Packages and installation

Source-provided package data. Koskamo has not executed or live-probed this package.

rosetta-mcp-server 1.3.1

npm

rosetta-mcp-server package definition

{
  "version": "1.3.1",
  "transport": "stdio",
  "identifier": "rosetta-mcp-server",
  "registryType": "npm",
  "environmentVariables": [
    {
      "name": "ROSETTA_BIN",
      "format": "string",
      "description": "Path to rosetta_scripts binary or its directory"
    },
    {
      "name": "PYTHON_BIN",
      "format": "string",
      "description": "Python interpreter with PyRosetta/Biotite installed"
    },
    {
      "name": "MCP_DEBUG",
      "format": "string",
      "description": "Set to 1 for debug logging"
    }
  ]
}

Tools

Reported by the attributed source; not independently observed by Koskamo.

No tool definitions available.

Connect from your client

Each snippet configures the same source-provided package; replace placeholders before use.

This server is operated by the named third party. Listing and endpoint checks are not an endorsement or a security audit. Review the operator's permissions, terms, and data handling before connecting. How listings are checked and corrected.

Cursor

Merge this local stdio configuration, replace every placeholder environment value, and restart Cursor. Koskamo has not executed this package.

Cursor configuration

{
  "mcpServers": {
    "rosetta-mcp-server": {
      "command": "npx",
      "args": [
        "-y",
        "rosetta-mcp-server@1.3.1"
      ],
      "env": {
        "ROSETTA_BIN": "<YOUR_ROSETTA_BIN>",
        "PYTHON_BIN": "<YOUR_PYTHON_BIN>",
        "MCP_DEBUG": "<YOUR_MCP_DEBUG>"
      }
    }
  }
}

Cline

Merge this local stdio configuration, replace every placeholder environment value, and restart Cline. Koskamo has not executed this package.

Cline configuration

{
  "mcpServers": {
    "rosetta-mcp-server": {
      "command": "npx",
      "args": [
        "-y",
        "rosetta-mcp-server@1.3.1"
      ],
      "env": {
        "ROSETTA_BIN": "<YOUR_ROSETTA_BIN>",
        "PYTHON_BIN": "<YOUR_PYTHON_BIN>",
        "MCP_DEBUG": "<YOUR_MCP_DEBUG>"
      }
    }
  }
}

VS Code

Merge this local stdio configuration, replace every placeholder environment value, and restart VS Code. Koskamo has not executed this package.

VS Code configuration

{
  "servers": {
    "rosetta-mcp-server": {
      "type": "stdio",
      "command": "npx",
      "args": [
        "-y",
        "rosetta-mcp-server@1.3.1"
      ],
      "env": {
        "ROSETTA_BIN": "<YOUR_ROSETTA_BIN>",
        "PYTHON_BIN": "<YOUR_PYTHON_BIN>",
        "MCP_DEBUG": "<YOUR_MCP_DEBUG>"
      }
    }
  }
}

Claude Desktop

Merge this local stdio configuration, replace every placeholder environment value, and restart Claude Desktop. Koskamo has not executed this package.

Claude Desktop configuration

{
  "mcpServers": {
    "rosetta-mcp-server": {
      "command": "npx",
      "args": [
        "-y",
        "rosetta-mcp-server@1.3.1"
      ],
      "env": {
        "ROSETTA_BIN": "<YOUR_ROSETTA_BIN>",
        "PYTHON_BIN": "<YOUR_PYTHON_BIN>",
        "MCP_DEBUG": "<YOUR_MCP_DEBUG>"
      }
    }
  }
}

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