Nullary MCP MCP server

An official MCP server by Nullary Analytics providing negative results intelligence for drug discovery. It allows agents to query 15.6M high-confidence findings of failed compounds, terminated trials, and failed CRISPR screens across seven modalities, enabling researchers to avoid dead-ends and ground models in validated failure data.

Endpoint and access

No sign-in: your client connects and lists tools immediately, with no account or key.

No sign-inEndpoint checked 2026-10-05Operated by Nullary Analytics

MCP endpoint (Streamable HTTP)

https://mcp.nullary.ai/mcp

Vendor documentation

What you can do with it

Query failed compounds and terminated trials by target or indication
Search inactive kinase inhibitors and antibody developability failures
Access provenance and citations for negative findings
Ground AI models in historical drug discovery failures

Tools advertised by the last live check:

search_inactive_compounds
search_failed_selectivity
search_admet_failures
search_failed_guides
search_failed_essentiality_screens
search_ancestry_specific_failures
search_developability_failures
search_failed_clinical_antibodies
search_failed_peptide_therapeutics
search_peptide_stability_issues
search_failed_protacs
search_protac_e3_issues
search_failed_oligonucleotides
search_oligo_delivery_failures
search_failed_vaccines
search_vaccine_immunogenicity_failures
search_failed_adcs
search_adc_linker_failures
search_failed_bispecifics
search_bispecific_format_failures
search_admet_failures_all_modalities
search_drug_drug_interaction_failures
search_mechanism_failures
search_failed_replications
search_safety_failures
search_target_history
search_indication_history
search_pathogen_history
get_compound
get_finding_provenance
get_target_landscape
list_top_targets
list_models
get_model_card
get_coverage

Connect from your client

Each snippet registers the same endpoint; pick the client you use.

This server is operated by the named third party. Listing and endpoint checks are not an endorsement or a security audit. Review the operator's permissions, terms, and data handling before connecting. How listings are checked and corrected.

Claude Code

Run this once in a terminal. It registers a Streamable HTTP server. Use --scope project to write .mcp.json for the repo.

Claude Code configuration

claude mcp add --transport http nullary-mcp https://mcp.nullary.ai/mcp

Codex

Run this once. Codex stores MCP servers in ~/.codex/config.toml (or .codex/config.toml in a trusted project).

Codex configuration

codex mcp add nullary-mcp --url https://mcp.nullary.ai/mcp

Cursor

Merge this server into .cursor/mcp.json in your project, then enable nullary-mcp in your MCP settings.

Cursor configuration

{
  "mcpServers": {
    "nullary-mcp": {
      "url": "https://mcp.nullary.ai/mcp"
    }
  }
}

Cline

Merge this into cline_mcp_settings.json (Cline → MCP Servers → Configure). The type must be streamableHttp for a remote HTTP server.

Cline configuration

{
  "mcpServers": {
    "nullary-mcp": {
      "type": "streamableHttp",
      "url": "https://mcp.nullary.ai/mcp",
      "disabled": false
    }
  }
}

VS Code

Merge this server into .vscode/mcp.json. Use MCP: List Servers to start nullary-mcp and inspect its tools.

VS Code configuration

{
  "servers": {
    "nullary-mcp": {
      "type": "http",
      "url": "https://mcp.nullary.ai/mcp"
    }
  }
}

Gemini CLI

Run this once. It writes .gemini/settings.json in the current project; pass --scope user for ~/.gemini/settings.json.

Gemini CLI configuration

gemini mcp add --transport http nullary-mcp https://mcp.nullary.ai/mcp

Claude Desktop

Merge this into claude_desktop_config.json (macOS: ~/Library/Application Support/Claude/, Windows: %APPDATA%\Claude\), then restart Claude Desktop.

Claude Desktop configuration

{
  "mcpServers": {
    "nullary-mcp": {
      "url": "https://mcp.nullary.ai/mcp"
    }
  }
}

Windsurf

Merge this into ~/.codeium/windsurf/mcp_config.json, then refresh MCP in Cascade. Windsurf remote servers use serverUrl, not url.

Windsurf configuration

{
  "mcpServers": {
    "nullary-mcp": {
      "serverUrl": "https://mcp.nullary.ai/mcp"
    }
  }
}

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