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Clinicaltrials MCP MCP server

An MCP server provided by Pipeworx that enables agents to search, analyze, and monitor ClinicalTrials.gov data. It offers tools to find trials by keyword, condition, or location; retrieve full study details and results; track sponsor pipelines and activity; and analyze phase transition rates and enrollment metrics.

Endpoint and access

No sign-in: your client connects and lists tools immediately, with no account or key.

No sign-inEndpoint checked 2026-10-05Operated by Pipeworx
MCP endpoint (Streamable HTTP)
https://gateway.pipeworx.io/clinicaltrials/mcp
Vendor documentation

What you can do with it

  • Search ClinicalTrials.gov for trials by keyword, condition, or phase
  • Retrieve full protocol and results details for a specific NCT ID
  • Analyze a sponsor's trial pipeline and competitive landscape
  • Track recent updates and enrollment status for active trials
Tools advertised by the last live check:
  • ask_pipeworx
  • ask_pipeworx_beta
  • ask_pipeworx_grounded
  • search_within
  • deep_research
  • discover_tools
  • resolve_entity
  • compare_entities
  • subscribe
  • unsubscribe
  • list_subscriptions
  • recent_alerts
  • entity_profile
  • recent_changes
  • validate_claim
  • company_facts
  • scan_dependency
  • bet_research
  • polymarket_arbitrage
  • polymarket_edges
  • polymarket_kalshi_spread
  • polymarket_fill_risk
  • polymarket_edge_tracker
  • kalshi_weather_edge
  • resolution_audit
  • resolution_diff
  • release_calendar_markets
  • pipeworx_trending
  • suggest_questions
  • generate_llms_txt
  • ai_visibility_check
  • scan_competitor_ai_presence
  • pipeworx_feedback
  • remember
  • recall
  • forget
  • ct_search
  • ct_get_study
  • ct_count_by_condition
  • ct_sponsor_trials
  • ct_compare_sponsors
  • ct_recent_updates
  • ct_trials_by_location
  • ct_catalyst_calendar
  • ct_sponsor_pipeline
  • ct_competitive_landscape
  • ct_enrollment_watch
  • ct_results_summary
  • ct_phase_transition_rates
  • ct_sponsor_activity

Connect from your client

Each snippet registers the same endpoint; pick the client you use.

This server is operated by the named third party. Listing and endpoint checks are not an endorsement or a security audit. Review the operator's permissions, terms, and data handling before connecting. How listings are checked and corrected.

Claude Code

Run this once in a terminal. It registers a Streamable HTTP server. Use --scope project to write .mcp.json for the repo.
Claude Code configuration
claude mcp add --transport http clinicaltrials-mcp https://gateway.pipeworx.io/clinicaltrials/mcp

Codex

Run this once. Codex stores MCP servers in ~/.codex/config.toml (or .codex/config.toml in a trusted project).
Codex configuration
codex mcp add clinicaltrials-mcp --url https://gateway.pipeworx.io/clinicaltrials/mcp

Cursor

Merge this server into .cursor/mcp.json in your project, then enable clinicaltrials-mcp in your MCP settings.
Cursor configuration
{
  "mcpServers": {
    "clinicaltrials-mcp": {
      "url": "https://gateway.pipeworx.io/clinicaltrials/mcp"
    }
  }
}

Cline

Merge this into cline_mcp_settings.json (Cline → MCP Servers → Configure). The type must be streamableHttp for a remote HTTP server.
Cline configuration
{
  "mcpServers": {
    "clinicaltrials-mcp": {
      "type": "streamableHttp",
      "url": "https://gateway.pipeworx.io/clinicaltrials/mcp",
      "disabled": false
    }
  }
}

VS Code

Merge this server into .vscode/mcp.json. Use MCP: List Servers to start clinicaltrials-mcp and inspect its tools.
VS Code configuration
{
  "servers": {
    "clinicaltrials-mcp": {
      "type": "http",
      "url": "https://gateway.pipeworx.io/clinicaltrials/mcp"
    }
  }
}

Gemini CLI

Run this once. It writes .gemini/settings.json in the current project; pass --scope user for ~/.gemini/settings.json.
Gemini CLI configuration
gemini mcp add --transport http clinicaltrials-mcp https://gateway.pipeworx.io/clinicaltrials/mcp

Claude Desktop

Merge this into claude_desktop_config.json (macOS: ~/Library/Application Support/Claude/, Windows: %APPDATA%\Claude\), then restart Claude Desktop.
Claude Desktop configuration
{
  "mcpServers": {
    "clinicaltrials-mcp": {
      "url": "https://gateway.pipeworx.io/clinicaltrials/mcp"
    }
  }
}

Windsurf

Merge this into ~/.codeium/windsurf/mcp_config.json, then refresh MCP in Cascade. Windsurf remote servers use serverUrl, not url.
Windsurf configuration
{
  "mcpServers": {
    "clinicaltrials-mcp": {
      "serverUrl": "https://gateway.pipeworx.io/clinicaltrials/mcp"
    }
  }
}

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